Villar H V, Reeder D D, Rayford P L, Thompson J C
Surgery. 1977 Apr;81(4):404-8.
In five awake mongrel dogs, endogenous gastrin was released by continuous irrigation of the antrum with acetylcholine. After 60 minutes of antral perfusion, the entire vascular supply of the antrum was suddenly and totally occluded, and serial samples of peripheral blood were taken for measurement of gastrin. The rate of disappearance of endogenous gastrin was caluclated by standard linear regression analysis; the calculated half-life of endogenous gastrin was 8.62 minutes. Analysis of the data suggests that the disappearance rate of endogenous gastrin could be explained by two distinct half-lives: one of 2.8 minutes (which is similar to the half-time in dogs of both 14- and 17 -amino acid gastrin), and another of 15.4 minutes (which is similar to the half-time of 34 -amino acid gastrin). Physiologically released gastrin is a mixture of three or more molecular forms of gastrin and the half-life of 8.62 minutes probably represents the disappearance half-time of this mixture.
在5只清醒的杂种犬中，通过用乙酰胆碱持续灌流胃窦来释放内源性胃泌素。在胃窦灌注60分钟后，突然完全阻断胃窦的整个血管供应，并采集外周血系列样本用于测量胃泌素。通过标准线性回归分析计算内源性胃泌素的消失率；计算出的内源性胃泌素半衰期为8.62分钟。数据分析表明，内源性胃泌素的消失率可用两个不同的半衰期来解释：一个为2.8分钟（与14和17个氨基酸的胃泌素在犬体内的半衰期相似），另一个为15.4分钟（与34个氨基酸的胃泌素的半衰期相似）。生理释放的胃泌素是三种或更多种胃泌素分子形式的混合物，8.62分钟的半衰期可能代表了这种混合物的消失半衰期。
