Vinik A I, Hickman R, Grant B J
S Afr Med J. 1978 May 13;53(19):759-65.
In vivo studies in the pig showed no net loss or gain of endogenous porcine gastrin during transport across the liver in fasting animals. Infusion of synthetic human heptadecapeptide gastrin (G-17) in doses of 0,25, 0,5 and 1,0 microgram/kg/min raised circulating gastrin levels to those found in the postprandial state. At no time was there a loss or gain of immunologically determined gastrin across the liver. Changes in the molecular size of gastrin, however, suggested that qualitative but not quantitative effects followed the administration of G-17 in vivo. The disappearance of gastrin from the circulation was biphasic, with an initial half-life of 3 minutes and a slower phase suggesting recirculation or multicompartment equilibration. The distribution at equilibrium was +/- 20% of body weight calculated from arterial levels, but 30-40% if portal or hepatic venous values were used. The mean blood production rate was +/- 125 microgram/day but the portal contribution was only 30 microgram/day, suggesting an important alternative source of gastrin.
在猪身上进行的体内研究表明，禁食动物肝脏转运过程中内源性猪胃泌素无净损失或增加。以0、0.25、0.5和1.0微克/千克/分钟的剂量输注合成人十七肽胃泌素（G-17），可使循环胃泌素水平升至餐后状态时的水平。在任何时候，肝脏中免疫测定的胃泌素均无损失或增加。然而，胃泌素分子大小的变化表明，体内给予G-17后会产生定性而非定量的影响。胃泌素从循环中的消失呈双相性，初始半衰期为3分钟，较慢的阶段提示再循环或多室平衡。根据动脉水平计算，平衡时的分布为体重的±20%，但如果使用门静脉或肝静脉值，则为30-40%。平均血液产生率为±125微克/天，但门静脉的贡献仅为30微克/天，这表明存在重要的胃泌素替代来源。
