Granulation tissue concentrations of ofloxacin after oral administration in invasive external otitis.

作者信息

Himmelfarb M Z, Zikk D, Rapoport Y, Redianu C, Shalit I

机构信息

Department of Otorhinolaryngology, Tel Aviv-Elias Sourasky Medical Center, Faculty of Medicine, University of Tel Aviv, Israel.

出版信息

Eur Arch Otorhinolaryngol. 1993;250 Suppl 1:S15-7. doi: 10.1007/BF02540111.

DOI:10.1007/BF02540111

PMID:8476580

Abstract

Following the fourth dose of 400 mg orally administered ofloxacin, simultaneous external ear canal granulation tissue and serum ofloxacin concentrations were estimated in 15 patients with invasive external otitis. The granulation tissue concentration was 2.2 (range 1.17-4.34) times higher than the serum concentration and 3.73 (range 1.95-11.00) times higher than the MIC90 of ofloxacin against Pseudomonas aeruginosa.

摘要