Lenarz T
ENT Department, University of Heidelberg.
Drugs. 1987;34 Suppl 1:139-43. doi: 10.2165/00003495-198700341-00030.
This study evaluated the therapeutic role of ofloxacin in different forms of otitis media. After identifying the infecting bacteria in 250 patients with acute otitis media, or chronic otitis media, the clinical efficacy of orally administered ofloxacin 200mg twice daily was assessed in 45 patients from each of these groups. The clinical results were comparable with those obtained after conventional local and oral antibiotic therapy. Microbiological examination of the ear secretions revealed Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae and Haemophilus influenzae to be the main pathogens in acute otitis media, whereas in chronic otitis media P. aeruginosa and Proteus sp. were detected in most of the cases. Ofloxacin concentrations in secretions and mucosa specimens of the middle ear exceeded serum concentrations by more than 2-fold. On the basis of these preliminary results, ofloxacin appears to be an effective orally administered agent, without ototoxicity, which is effective against S. aureus and P. aeruginosa, 2 important pathogens in middle ear infections. Ofloxacin should be considered as an alternative for the therapy of otitis media, especially the chronic forms.
本研究评估了氧氟沙星在不同类型中耳炎中的治疗作用。在确定250例急性中耳炎或慢性中耳炎患者的感染细菌后，对每组45例患者评估了每日口服200mg氧氟沙星两次的临床疗效。临床结果与传统局部及口服抗生素治疗后的结果相当。耳部分泌物的微生物学检查显示，金黄色葡萄球菌、化脓性链球菌、肺炎链球菌和流感嗜血杆菌是急性中耳炎的主要病原体，而在慢性中耳炎中，大多数病例检测到铜绿假单胞菌和变形杆菌属。中耳分泌物和黏膜标本中的氧氟沙星浓度超过血清浓度两倍以上。基于这些初步结果，氧氟沙星似乎是一种有效的口服药物，无耳毒性，对金黄色葡萄球菌和铜绿假单胞菌有效，这两种是中耳感染中的重要病原体。氧氟沙星应被视为中耳炎治疗的替代药物，尤其是慢性中耳炎。
