Seidel C, Schaefer F, Schärer K
Division of Pediatric Nephrology, University Children's Hospital, Heidelberg, Germany.
Pediatr Nephrol. 1993 Apr;7(2):151-5. doi: 10.1007/BF00864383.
Body height and height velocity were analysed in 54 children with obstructive urinary tract malformations over a mean period of 8.7 years, using new auxological methods. At the time of diagnosis, 9% of patients had a height of more than 2 standard deviations below the normal mean. Mean relative height changed significantly from the first to the last observation, the standard deviation score (SDS) increasing from -0.16 to +0.36 in patients with hydronephrosis compared with normal children (P < 0.05) and from -0.63 to +0.02 SDS in those without hydronephrosis (P < 0.005). The pathogenesis of the described growth disturbance is not clear. Stepwise multiple regression analysis pointed to a possible link between the duration of antibiotic treatment and the recovery of growth capacity, but improved growth could not clearly be attributed to any medical or surgical treatment. The synchronized average growth velocity curve was similar to that of healthy children and showed a normal pubertal spurt. Final height and target height calculated from parents' height differed only slightly from that of the normal population.
采用新的体格测量方法，对54例患有梗阻性尿路畸形的儿童进行了平均8.7年的身高及身高增长速度分析。诊断时，9%的患者身高低于正常均值2个标准差以上。从首次观察到末次观察，平均相对身高发生了显著变化，与正常儿童相比，肾积水患者的标准差评分（SDS）从-0.16增加到+0.36（P<0.05），无肾积水患者的SDS从-0.63增加到+0.02（P<0.005）。所描述的生长障碍的发病机制尚不清楚。逐步多元回归分析指出抗生素治疗持续时间与生长能力恢复之间可能存在联系，但生长改善不能明确归因于任何药物或手术治疗。同步平均生长速度曲线与健康儿童相似，并显示出正常的青春期生长突增。根据父母身高计算的最终身高和靶身高与正常人群仅略有差异。
