芳香化酶和硫酸雌酮酶在人类乳腺癌中的预后意义

Prognostic significance of aromatase and estrone sulfatase enzymes in human breast cancer.

作者信息

Evans T R, Rowlands M G, Silva M C, Law M, Coombes R C

机构信息

Department of Medical Oncology, St George's Hospital Medical School, London, England.

出版信息

J Steroid Biochem Mol Biol. 1993 Mar;44(4-6):583-7. doi: 10.1016/0960-0760(93)90263-v.

DOI:10.1016/0960-0760(93)90263-v

PMID:8476770

Abstract

The aromatase and estrone sulfatase enzymes are important sources of local synthesis of biologically active estrogens in human breast cancer. Significant intratumoral aromatase activity was detected in 91/145 (63%) of tumors and estrone sulfatase was detected in 93/104 (89%) of tumors. There was no relationship between aromatase activity and tumor size, site, nodal status, menopausal status or estrogen receptor status. There was a significant correlation between the aromatase activity and histological grade, with an excess of aromatase-positive in the high grade tumors (P = 0.03). There was a marginally inverse correlation between the aromatase activity and time to relapse (P < 0.1), a significant correlation between aromatase activity and survival after relapse (P < 0.05) but not with overall survival (P > 0.1). Intratumoral estrone sulfatase activity was not significantly correlated to any putative prognostic factors, nor with time to relapse nor overall survival time.

摘要

芳香化酶和雌酮硫酸酯酶是人类乳腺癌中生物活性雌激素局部合成的重要来源。在145个肿瘤中的91个（63%）检测到显著的肿瘤内芳香化酶活性，在104个肿瘤中的93个（89%）检测到雌酮硫酸酯酶。芳香化酶活性与肿瘤大小、部位、淋巴结状态、绝经状态或雌激素受体状态之间没有关系。芳香化酶活性与组织学分级之间存在显著相关性，高级别肿瘤中芳香化酶阳性过多（P = 0.03）。芳香化酶活性与复发时间之间存在微弱的负相关（P < 0.1），芳香化酶活性与复发后的生存率之间存在显著相关性（P < 0.05），但与总生存率无关（P > 0.1）。肿瘤内雌酮硫酸酯酶活性与任何假定的预后因素均无显著相关性，与复发时间或总生存时间也无相关性。