Smitt P A, Troost D, Louwerse E S, de Jong J M, van Kessel D T, de Leeuw M A
Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands.
Clin Neuropathol. 1993 Mar-Apr;12(2):88-91.
An autopsy study was performed on temporal lobe samples from 20 non-demented patients with amyotrophic lateral sclerosis (ALS), 17 age-matched non-demented controls and 4 Alzheimer's disease (AD) patients. Formalin fixed, paraffin embedded sections from the hippocampus with adjacent parahippocampal gyrus and from the superior temporal gyrus were stained with conventional and immunohistochemical stains. Immunohistochemical staining for the A4 protein was enhanced by pretreatment with 0.25% pepsin before 100% formic acid. The incidence and severity of AD-like pathological changes were similar in ALS patients and non-demented controls. In both groups, pathological changes increased with age. This study does not support the hypothesis that ALS and AD share an etiopathogenetic background.
对20例非痴呆型肌萎缩侧索硬化症（ALS）患者、17例年龄匹配的非痴呆对照者以及4例阿尔茨海默病（AD）患者的颞叶样本进行了尸检研究。对来自海马体及其相邻的海马旁回以及颞上回的福尔马林固定、石蜡包埋切片进行了常规染色和免疫组织化学染色。在用100%甲酸处理之前，先用0.25%胃蛋白酶预处理，增强A4蛋白的免疫组织化学染色。ALS患者和非痴呆对照者中AD样病理变化的发生率和严重程度相似。在两组中，病理变化均随年龄增长而增加。本研究不支持ALS和AD具有共同病因学背景这一假说。
