Hochlowski J E, Mullally M M, Spanton S G, Whittern D N, Hill P, McAlpine J B
Abbott Laboratories, Abbott Park, Illinois 60064.
J Antibiot (Tokyo). 1993 Mar;46(3):380-6. doi: 10.7164/antibiotics.46.380.
A family of novel compounds has been detected and isolated following an assay for the attenuation of multiple drug resistance in tumor cells from the fermentation broth and mycelia of a strain of Aspergillus fischeri which we have designated var. brasiliensis. The structures of three components were determined employing 1-D and 2-D homonuclear and heteronuclear NMR spectroscopy and mass spectrometry. The structure of 5-N-acetylardeemin was confirmed by single crystal X-ray diffraction. These compounds are most closely structurally related to asperlicin E1).
在对一株我们命名为巴西变种的费氏曲霉发酵液和菌丝体中肿瘤细胞多药耐药性的衰减检测后，检测并分离出了一类新型化合物。利用一维和二维同核及异核核磁共振光谱法和质谱法确定了三种成分的结构。通过单晶X射线衍射证实了5-N-乙酰阿地米星的结构。这些化合物在结构上与曲霉利辛E1最为密切相关。
