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5-N-acetylardeemin, a novel heterocyclic compound which reverses multiple drug resistance in tumor cells. I. Taxonomy and fermentation of the producing organism and biological activity.

作者信息

Karwowski J P, Jackson M, Rasmussen R R, Humphrey P E, Poddig J B, Kohl W L, Scherr M H, Kadam S, McAlpine J B

机构信息

Abbott Laboratories, Abbott Park, Illinois 60064.

出版信息

J Antibiot (Tokyo). 1993 Mar;46(3):374-9. doi: 10.7164/antibiotics.46.374.

DOI:10.7164/antibiotics.46.374
PMID:8478255
Abstract

The ardeemins are a new family of secondary metabolites produced by submerged fermentation of a fungus which was isolated from a soil sample collected in Brazil. Based on taxonomic studies, the producing culture was identified as Aspergillus fischeri var. brasiliensis strain AB 1826M-35. 5-N-Acetylardeemin potentiated the cytotoxicity of the anticancer agent vinblastine in multidrug resistant human tumor cells.

摘要

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