Pradimicins FS and FB, new pradimicin analogs: directed production, structures and biological activities.
作者信息
Saitoh K, Suzuki K, Hirano M, Furumai T, Oki T
机构信息
Bristol-Myers Squibb Research Institute, Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1993 Mar;46(3):398-405. doi: 10.7164/antibiotics.46.398.
PMID:8478258
Abstract
Exogenous addition of D-serine to Actinomadura spinosa AA0851 resulted in directed production of pradimicin FS, a new D-serine analog of pradimicin S, together with pradimicin FB. Pradimicin FS was produced in higher yields by derivation of ferrous sulfate-resistant strains from strain AA0851. Pradimicin FB, a minor product, was identified as deglucosylpradimicin FL. Pradimicin FS was equivalent to pradimicin S in syncytium formation inhibition activity and in vitro and in vivo antifungal activities.
摘要
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