Stover P, Schirch V
Department of Biochemistry, Virginia Commonwealth University, Richmond 23298.
Trends Biochem Sci. 1993 Mar;18(3):102-6. doi: 10.1016/0968-0004(93)90162-g.
Interest in determining if leucovorin, known chemically as 5-formyltetra-hydrofolate, plays a role in one-carbon metabolism is reemerging. While investigations in the 1940s suggested it was an important donor of one-carbon units in folate-mediated biosynthetic reactions, studies between the 1950s and 1980s disproved this hypothesis and dismissed its presence in biological systems as artifactual. Recently, new data has focused attention on the possible biological function of this compound that is widely used in cancer chemotherapy.
对于确定化学名称为5-甲酰四氢叶酸的亚叶酸是否在一碳代谢中发挥作用的研究兴趣正在重新兴起。虽然20世纪40年代的研究表明它是叶酸介导的生物合成反应中一碳单位的重要供体，但20世纪50年代至80年代的研究推翻了这一假设，并将其在生物系统中的存在视为人为现象而不予考虑。最近，新的数据使人们将注意力集中在这种广泛用于癌症化疗的化合物可能具有的生物学功能上。
