Kaltwasser K, Kleinau H, Pankow D, Ponsold W, Strahl U
Z Exp Chir. 1977;10(1):45-51.
The lethality of 187 patients with severe carbon monoxide intoxication was investigated in relation to body temperature. 22 per cent of the normothermic, but 36 per cent of hypothermic or hyperthermic patients did not survive the carbon monoxide poisoning. The lethality increases following enhancement of degree and duration of hypothermia. Pretreatment of rats with chlorpromazine producing a decrease of body temperature of 4 degree C induces a small reduction of toxicity after subcutaneous carbon monoxide injection. However, the CO-DL50 decreases from 17 to 11,5 mmol/kg following administration of the same dose of chlorpromazine after carbon monoxide injection. Changes in carboxyhemoglobin levels are consistent with alterations of CO toxicity. On the basis of these results, it appears that it is not advisable to maintain a spontaneous hypothermia during carbon monoxide intoxication.
对187例重度一氧化碳中毒患者的致死率与体温的关系进行了研究。体温正常的患者中有22%未能从一氧化碳中毒中存活，但体温过低或过高的患者中这一比例为36%。随着体温过低程度的加重和持续时间的延长，致死率增加。用氯丙嗪对大鼠进行预处理，使其体温降低4℃，皮下注射一氧化碳后毒性略有降低。然而，注射一氧化碳后给予相同剂量的氯丙嗪，一氧化碳半数致死剂量（CO-DL50）从17mmol/kg降至11.5mmol/kg。碳氧血红蛋白水平的变化与一氧化碳毒性的改变一致。基于这些结果，似乎在一氧化碳中毒期间维持自发性体温过低是不可取的。
