Grazioso C F, Isalgué M, de Ramírez I, Ruz M, Solomons N W
Center for Studies of Sensory Impairment, Aging and Metabolism, National Committee for the Blind and Deaf, Guatemala City, Guatemala.
Am J Clin Nutr. 1993 May;57(5):673-8. doi: 10.1093/ajcn/57.5.673.
One hundred thirty children (65-95 mo old) from a low-socioeconomic neighborhood of Guatemala City participated in a randomized, double-blind, controlled trial of zinc supplementation. One group received 10 mg Zn/d (n = 65) and the other group received a placebo (n = 65); 90 +/- 9.2 doses were given over 120-150 d. Stools were examined for prevalence and intensity of helminths and prevalence of protozoa at the beginning and end of the study. The initial prevalence was 42% for helminths and 18% for protozoa, with no differences between groups. Mebendazole was administered to all children, and protozoal infections were treated specifically at the beginning of the study. The reinfection rates were 17% (11 of 65) for helminths and 12.3% (8 of 65) for protozoa in the zinc group and 15% (10 of 65) and 10.7% (7 of 65), respectively, in the placebo group (P > 0.05). Analysis by specific parasites revealed no treatment effect. We conclude that neither plasma or hair zinc status nor oral zinc supplementation had an effect on parasite status in children.
来自危地马拉城一个社会经济地位较低社区的130名儿童（65 - 95个月大）参与了一项补锌的随机、双盲、对照试验。一组儿童每天接受10毫克锌（n = 65），另一组接受安慰剂（n = 65）；在120 - 150天内给予90±9.2剂。在研究开始和结束时检查粪便中蠕虫的流行率和感染强度以及原生动物的流行率。初始蠕虫流行率为42%，原生动物为18%，两组之间无差异。在研究开始时给所有儿童服用甲苯达唑，并对原生动物感染进行针对性治疗。锌组蠕虫再感染率为17%（65例中的11例），原生动物为12.3%（65例中的8例），安慰剂组分别为15%（65例中的10例）和10.7%（65例中的7例）（P>0.05）。按特定寄生虫进行分析未发现治疗效果。我们得出结论，血浆或头发锌状态以及口服补锌对儿童的寄生虫状态均无影响。
