Cavan K R, Gibson R S, Grazioso C F, Isalgue A M, Ruz M, Solomons N W
Division of Applied Human Nutrition, University of Guelph, Ontario, Canada.
Am J Clin Nutr. 1993 Mar;57(3):344-52. doi: 10.1093/ajcn/57.3.344.
Changes in growth, body composition, and zinc indexes were evaluated after 25 wk in a double-blind zinc-supplementation study of 162 periurban Guatemalan children aged 81.5 +/- 7.0 mo (mean +/- SD). Children receiving the zinc supplement (10 mg Zn/d as amino acid chelate) for 90.1 +/- 9.2 d had higher mean fasting plasma zinc (16.2 +/- 2.9 vs 14.9 +/- 2.1 mumol/L, P < 0.01), a greater increase in median triceps skinfold Z score (0.50 vs 0.38, P < 0.05), and a smaller deficit in median midarm circumference (MAC) Z score (-0.03 vs -0.20, P < 0.05) compared with the placebo group. Initial hair zinc classified as < 1.68 and > 1.68 mumol/g was the only laboratory variable that explained some of the variance in final Z scores of midarm-muscle area (P < 0.05) and MAC (P < 0.01). Children responded to the zinc supplement with changes in indexes of body composition rather than growth.
在一项针对162名危地马拉城郊81.5±7.0个月（均值±标准差）儿童的双盲补锌研究中，25周后评估了生长、身体成分和锌指标的变化。接受90.1±9.2天补锌（10毫克锌/天，以氨基酸螯合物形式）的儿童，其空腹血浆锌均值更高（16.2±2.9对14.9±2.1微摩尔/升，P<0.01），肱三头肌皮褶厚度Z评分中位数的增加幅度更大（0.50对0.38，P<0.05），与安慰剂组相比，上臂中部周长（MAC）Z评分中位数的不足更小（-0.03对-0.20，P<0.05）。初始头发锌含量分为<1.68和>1.68微摩尔/克，是唯一能解释上臂肌肉面积最终Z评分（P<0.05）和MAC（P<0.01）部分差异的实验室变量。儿童对补锌的反应是身体成分指标发生变化，而非生长指标。
