Mellink J J, Vos B J
Z Parasitenkd. 1977 Mar 29;51(2):187-98. doi: 10.1007/BF00500958.
Post-auricular lymph node responses and changes in fresh weight of thymus and spleen of hamsters and mice at 4 and 8 days after primary exposure of both ears to 20 bites by the mosquito Aedes aegypti were studied quantitatively. In both hosts lymph node changes characteristic of the development of cell-mediated immune responses and those which are believed to lead to antibody production occurred, with the emphasis on the latter phenomena. No reactions of thymus and spleen were observed. The responses recorded are considered to be immunologically specific. In hamsters, but not in mice, the responses related to humoral sensitization coincided in time to a large extent with those of the cell-mediated immune processes. The stronger humoral responses in mice were probably in the first place the result of the relatively higher dosages applied.
对仓鼠和小鼠双耳初次暴露于埃及伊蚊叮咬20次后的第4天和第8天，研究了耳后淋巴结反应以及胸腺和脾脏鲜重的变化。在两种宿主中，均出现了细胞介导免疫反应发展所特有的淋巴结变化以及据信会导致抗体产生的变化，且重点在于后一种现象。未观察到胸腺和脾脏有反应。所记录的反应被认为具有免疫特异性。在仓鼠中，而非小鼠中，与体液致敏相关的反应在很大程度上与细胞介导免疫过程的反应在时间上相吻合。小鼠中较强的体液反应可能首先是应用了相对较高剂量的结果。
