Schuckit M A, Smith T L, Anthenelli R, Irwin M
Department of Psychiatry, University of California, School of Medicine, San Diego.
Am J Psychiatry. 1993 May;150(5):786-92. doi: 10.1176/ajp.150.5.786.
This study was undertaken to determine the relative order of appearance of symptoms in alcohol dependence.
The age at which 21 alcohol-related major life events first occurred was investigated in 636 male alcohol-dependent inpatients through a standardized, structured personal interview with each subject and at least one resource person.
A general pattern of first occurrence of these events was observed. Heavy drinking escalated further when the subjects were in their late 20s, followed by evidence of interference with functioning in multiple life areas in the early 30s, a subsequent perception of loss of control, and then an intensification of social and job-related problems, along with evidence of deterioration in body systems, in the mid- to late 30s. Similar patterns of problems emerged when the alcoholic subjects were divided into subgroups based on onset of alcohol dependence before or after age 30, presence or absence of a family history of alcoholism, and presence or absence of additional psychiatric disorders.
These data indicate that there is a typical progression of events related to alcohol dependence. This information can be useful for clinicians in their work with patients and for teachers and researchers as well.
本研究旨在确定酒精依赖中症状出现的相对顺序。
通过对636名男性酒精依赖住院患者进行标准化、结构化的个人访谈，并与至少一名信息提供者交流，调查21项与酒精相关的重大生活事件首次发生的年龄。
观察到这些事件首次发生的一般模式。受试者在快30岁时重度饮酒进一步升级，随后在30岁出头时出现多个生活领域功能受干扰的迹象，接着是对失去控制的感知，然后在35岁至40岁时社会和工作相关问题加剧，同时身体系统出现恶化迹象。当根据30岁之前或之后开始酒精依赖、有无酒精ism家族史以及有无其他精神障碍将酒精依赖受试者分为亚组时，出现了类似的问题模式。
这些数据表明，与酒精依赖相关的事件存在典型的进展过程。这些信息对临床医生治疗患者以及教师和研究人员都有用。
