二胺和多胺的抗氧化特性。

Antioxidant properties of di- and polyamines.

Matkovics B, Kecskemeti V, Varga S I, Novak Z, Kertesz Z

Biological Isotope Laboratory, József Attila University of Szeged, Hungary.

Comp Biochem Physiol B. 1993 Mar;104(3):475-9. doi: 10.1016/0305-0491(93)90269-b.

Abstract

One diamine, putrescine and two polyamines, spermidine and spermine (PAs) of different concentrations, were processed through antioxidant systems in order to study their antioxidant effects. The systems investigated were as follows. 2. "Oxidative stress" was induced in RBCs to investigate filtration parameters, the effect of reduced glutathione (GSH) and the change in lipid peroxidation (LP) superoxide dismutase (SOD) activities. 3. Initiated LP-decreasing characteristics of the substances were studied in pig brain homogenate. 4. The LP-decreasing effect of these PAs were studied in guinea-pig heart tissue homogenate perfused with Tyrode solution, stimulated, and then perfused by the Langendorff method. 5. In all three tests, the antioxidant characteristics of PAs were unambiguously proved.

摘要

为研究不同浓度的一种二胺（腐胺）和两种多胺（亚精胺和精胺）的抗氧化作用，使其通过抗氧化系统进行处理。所研究的系统如下。2. 在红细胞中诱导“氧化应激”，以研究过滤参数、还原型谷胱甘肽（GSH）的作用以及脂质过氧化（LP）、超氧化物歧化酶（SOD）活性的变化。3. 在猪脑匀浆中研究了这些物质降低LP的特性。4. 在灌注台氏液、受到刺激然后采用Langendorff方法灌注的豚鼠心脏组织匀浆中研究了这些多胺降低LP的作用。5. 在所有这三项试验中，均明确证明了多胺的抗氧化特性。