利用人体红细胞对多胺的抗过氧化物和抗溶血作用的研究。
Studies on the antiperoxide and antihaemolytic action of polyamines using human erythrocytes.
作者信息
Chetan C, Prabhu A, D'Souza V, Rao S B
机构信息
Department of Biochemistry, Kasturba Medical College, 575 001 Mangalore.
出版信息
Indian J Clin Biochem. 2000 Aug;15(1):17-21. doi: 10.1007/BF02873542.
Blood RBC's were used to study the role of polyamines, putrescine, spermidine and spermine individually as antioxidants against the peroxidative action of H(2)O(2) which leads to haemolysis of erythrocytes. Results indicated that putrescine did not act as antioxidant at all concentrations used in our studies. However, spermidine and spermine suppressed peroxidative changes in RBC's due to the action of H(2)O(2) and this suppression was greater with higher concentration of these individual polyamines used, separately. Further, all the three polyamines decreased haemolysis of erythrocytes at all concentrations studied. The action of putrescine to suppress haemolysis of RBC's without showing antioxidant property hypothetically suggests that these properties of respective polyamines may have independent mechanism of action.
血液红细胞被用于单独研究多胺、腐胺、亚精胺和精胺作为抗氧化剂对H₂O₂过氧化作用的影响，H₂O₂的过氧化作用会导致红细胞溶血。结果表明，在我们研究中使用的所有浓度下，腐胺都没有起到抗氧化剂的作用。然而，亚精胺和精胺抑制了由于H₂O₂作用导致的红细胞过氧化变化，并且分别使用这些单个多胺的浓度越高，这种抑制作用越强。此外，在所有研究浓度下，这三种多胺都降低了红细胞的溶血。腐胺在不表现出抗氧化特性的情况下抑制红细胞溶血的作用，从假设角度表明这些各自多胺的特性可能具有独立的作用机制。
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