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小鼠潜在性维生素A缺乏对针对绵羊红细胞的体液抗体产生及对单核细胞增多性李斯特菌感染抵抗力的影响(作者译)

[Influence of latent vitamin A deficiency of the mouse on the production of humoral antibodies against sheep erythrocytes and on the resistance against infection with Listeria monocytogenes (author's transl)].

作者信息

Hof H, Emmerling P, Finger H, Wirsing C, Karle E, Reiners W

出版信息

Zentralbl Bakteriol Orig A. 1977;237(2-3):310-7.

PMID:848214
Abstract

Mice fed with a vitamin A free diet for several months did not develop signs of vitamin A deficiency. However, chemical analysis revealed a reduced content of vitamin A in the liver of such mice. The ability of these animals were latent vitamin A deficiency to produce antibodies against parenterally applicated sheep erythrocytes was not hampered. Similar numbers of antibody producing cells could be detected in the spleen of these mice compared with control animals. Resistance against intravenous infection with L. monocytogenes of these mice with latent vitamin A deficiency was not altered. The numbers of viable germs recovered from spleen and liver 2 days after infection were similar in both vitamin A deprived and normal mice.

摘要

用不含维生素A的饲料喂养数月的小鼠并未出现维生素A缺乏的迹象。然而,化学分析显示这些小鼠肝脏中的维生素A含量有所降低。这些存在潜在维生素A缺乏的动物产生针对经肠胃外注射的绵羊红细胞的抗体的能力并未受到阻碍。与对照动物相比,在这些小鼠的脾脏中可检测到数量相似的抗体产生细胞。这些存在潜在维生素A缺乏的小鼠对单核细胞增生李斯特菌静脉感染的抵抗力没有改变。在感染后2天,从维生素A缺乏小鼠和正常小鼠的脾脏和肝脏中回收的活菌数量相似。

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