Jähne J, Urmacher C, Cordon-Cardo C, Meyer H J, Pichlmayr R
Klinik für Abdominal- und Transplantationschirurgie, Medizinische Hochschule Hannover.
Chirurg. 1993 Apr;64(4):275-8.
The DNA status and the proliferative activity was determined in 37 gastric carcinomas applying computerized image analysis. Aneuploidy was found in 51.4% (n = 19) of the tumors. Comparing diploid and aneuploid lesions the latter ones had statistically significant increased DNA amount, DNA index and proliferative rate (7.4 pg, 1.03 and 16.4% versus 12.8 pg, 1.78 and 30.7%; p < 0.05). Aneuploidy occurred more frequently in tumors at proximal sites (p < 0.05), but was not associated with histological type, differentiation and tumor stage. The prognostic impact of DNA aneuploidy remains controversial, since tumor aggressiveness per se is not directly related to aneuploidy.
运用计算机图像分析技术，对37例胃癌的DNA状态和增殖活性进行了测定。在51.4%（n = 19）的肿瘤中发现了非整倍体。比较二倍体和非整倍体病变，后者的DNA含量、DNA指数和增殖率在统计学上显著增加（分别为7.4 pg、1.03和16.4%，对比12.8 pg、1.78和30.7%；p < 0.05）。非整倍体在近端部位的肿瘤中更常见（p < 0.05），但与组织学类型、分化程度和肿瘤分期无关。DNA非整倍体的预后影响仍存在争议，因为肿瘤的侵袭性本身与非整倍体并无直接关联。
