饥饿对大鼠肾脏过氧化物酶体和微粒体脂肪酸氧化的影响。肝脏与肾脏的比较研究。

Starvation effect on rat kidney peroxisomal and microsomal fatty acid oxidation. A comparative study between liver and kidney.

作者信息

Orellana M, Fuentes O, Valdés E

机构信息

Departamento de Bioquimica, Facultad de Medicina, Universidad de Chile, Santiago.

出版信息

FEBS Lett. 1993 May 3;322(1):61-4. doi: 10.1016/0014-5793(93)81111-c.

DOI:10.1016/0014-5793(93)81111-c

PMID:8482369

Abstract

Microsomal lauric acid 12-hydroxy lauric acid (omega)-hydroxylation and fatty acid peroxisomal beta-oxidation were studied in kidney tissue from starved rats. Starvation increased the microsomal omega-hydroxylation and peroxisomal beta-oxidation of fatty acids with a high correlation between both processes. Earlier, we reported similar results in liver. Our results support the hypothesis that the role of microsomal fatty acids omega-hydroxylation is the generation of substrate for peroxisomal beta-oxidation, with the final purpose of contributing to a catabolic or gluconeogenic pathway from fatty acids.

摘要

在饥饿大鼠的肾脏组织中研究了微粒体月桂酸12-羟基月桂酸（ω）-羟基化和脂肪酸过氧化物酶体β-氧化。饥饿增加了微粒体ω-羟基化和脂肪酸过氧化物酶体β-氧化，且这两个过程之间具有高度相关性。此前，我们在肝脏中也报道过类似结果。我们的结果支持这样的假说，即微粒体脂肪酸ω-羟基化的作用是为过氧化物酶体β-氧化生成底物，最终目的是促进脂肪酸的分解代谢或糖异生途径。