长期乙醇摄入后大鼠肝脏中过氧化物酶体和微粒体脂肪酸氧化情况
Peroxisomal and microsomal fatty acid oxidation in liver of rats after chronic ethanol consumption.
作者信息
Orellana M, Rodrigo R, Valdés E
机构信息
ICBM, Programa de Farmacología, Molecular Y Clínica, Facultad de Medicina, Universidad de Chile, Santiago.
出版信息
Gen Pharmacol. 1998 Nov;31(5):817-20. doi: 10.1016/s0306-3623(98)00054-8.
PMID:9809485
Abstract
- Microsomal P450 and peroxisomal fatty acid oxidation activities were studied in liver of rats after long-term ethanol consumption. 2. Ethanol increased the microsomal lauric acid omega-hydroxylation and the aminopyrine N-demethylation catalyzed by cytochrome P450. 3. Ethanol increased peroxisomal beta-oxidation of palmitoyl CoA and catalase activity in liver. 4. Both microsomal and peroxisomal activities behaved in a coordinate way in the liver of rats with long-term ethanol consumption. 5. These results would support a role of microsomal omega-hydroxylation and peroxisomal beta-oxidation of fatty acids in an extramitochondrial pathway of lipid oxidation in the liver.
摘要
- 研究了长期摄入乙醇后大鼠肝脏中的微粒体P450和过氧化物酶体脂肪酸氧化活性。2. 乙醇增加了细胞色素P450催化的微粒体月桂酸ω-羟化作用和氨基比林N-脱甲基作用。3. 乙醇增加了肝脏中过氧化物酶体棕榈酰辅酶A的β-氧化作用和过氧化氢酶活性。4. 在长期摄入乙醇的大鼠肝脏中，微粒体和过氧化物酶体的活性呈现协同作用。5. 这些结果支持了微粒体ω-羟化作用和过氧化物酶体脂肪酸β-氧化作用在肝脏脂质氧化的线粒体外途径中的作用。
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