饥饿对大鼠肝脏过氧化物酶体和微粒体脂肪酸氧化的调节作用。

Modulation of rat liver peroxisomal and microsomal fatty acid oxidation by starvation.

作者信息

Orellana M, Fuentes O, Rosenbluth H, Lara M, Valdés E

机构信息

Departamento de Bioquímica, Facultad de Medicina, Universidad de Chile, Santiago.

出版信息

FEBS Lett. 1992 Sep 28;310(2):193-6. doi: 10.1016/0014-5793(92)81327-i.

DOI:10.1016/0014-5793(92)81327-i

PMID:1397271

Abstract

In this work the microsomal lauric acid omega-hydroxylation, fatty acid peroxisomal beta-oxidation, and the levels of cytochrome P-450 IVA1 were studied in liver tissue from starved rats. Starvation increased the peroxisomal beta-oxidation and the microsomal hydroxylation of fatty acids. The correlation between these activities would support the proposal that both processes are linked, contributing in part to catabolism of fatty acids in liver of starved rats.

摘要

在本研究中，对饥饿大鼠肝脏组织中的微粒体月桂酸ω-羟化、脂肪酸过氧化物酶体β-氧化以及细胞色素P-450 IVA1水平进行了研究。饥饿增加了过氧化物酶体β-氧化和脂肪酸的微粒体羟化。这些活性之间的相关性支持了这一观点，即这两个过程相互关联，部分促成了饥饿大鼠肝脏中脂肪酸的分解代谢。