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关于复杂部分性发作的遗传学:对同胞兄弟姐妹进行清醒和睡眠脑电图研究

On the genetics of complex partial seizures: waking and sleep EEGs in siblings.

作者信息

Degen R, Degen H E, Köneke B

机构信息

Epilepsiezentrum Bethel, Bielefeld, Germany.

出版信息

J Neurol. 1993;240(3):151-5. doi: 10.1007/BF00857520.

DOI:10.1007/BF00857520
PMID:8482987
Abstract

Waking and sleep EEGs were recorded in 29 siblings of 19 patients with complex partial seizures. At least 1 sibling with epileptic activity (EA) was found for 36.8% of the patients. Taking the 29 siblings as a basis, in 7 EA was recorded. Most EA was seen during sleep in stage C (29%). More EA was recorded in female siblings (28%: 18%) and in siblings of female patients (56%: 20%). All EA was seen in the age range 5-14 years. Siblings with occipital theta-delta activity with a generalization tendency showed more EA (59%) than those without this pattern (8%). Of the siblings of patients with generalized EA 50% showed EA, but only 25% of those of patients with localized EEG patterns.

摘要

对19例复杂部分性癫痫患者的29名同胞进行了清醒和睡眠脑电图记录。在36.8%的患者中发现至少有1名同胞存在癫痫样活动(EA)。以这29名同胞为基础,记录到7例EA。大多数EA出现在睡眠C期(29%)。女性同胞中记录到的EA更多(28%:18%),女性患者的同胞中记录到的EA也更多(56%:20%)。所有EA均出现在5至14岁的年龄范围内。具有枕区θ-δ活动且有泛化倾向的同胞出现EA的比例(59%)高于无此模式的同胞(8%)。全身性EA患者的同胞中有50%出现EA,但局限性脑电图模式患者的同胞中只有25%出现EA。

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