Coeugniet E, Bendtzen K, Soeberg B, Bendixen G
Acta Med Scand. 1977;201(3):197-201.
Lymphocytes from 14 patients treated with a combination of acetylsalicylic acid (ASA) and dipyridamole (DIPY) showed a decreased ability to produce leucocyte migration inhibitory activity (LMIA) when stimulated with concanavalin-A (ConA). The combined treatment also produced a decrease of leucocyte response to a standard LMIA-containing culture supernatant. Treatment with only one of the two drugs did not cause detectable alteration of the lymphocyte response to Con-A or the leucocyte response to LMIA. In vitro, both DIPY and ASA were independently effective in decreasing the LMIA production of Con-A-stimulated lymphocytes and the leucocyte response to a standard LMIA-containing culture supernatant.
14名接受乙酰水杨酸（ASA）和双嘧达莫（DIPY）联合治疗的患者的淋巴细胞在用刀豆球蛋白-A（ConA）刺激时，产生白细胞迁移抑制活性（LMIA）的能力下降。联合治疗还导致白细胞对含标准LMIA的培养上清液的反应降低。仅使用两种药物中的一种进行治疗，未引起淋巴细胞对Con-A的反应或白细胞对LMIA的反应有可检测到的改变。在体外，DIPY和ASA均可独立有效地降低Con-A刺激的淋巴细胞的LMIA产生以及白细胞对含标准LMIA的培养上清液的反应。
