Mobarok A T, Morley J
Agents Actions. 1980 Dec;10(6):509-12. doi: 10.1007/BF02024153.
The actions of aspirin and dipyridamole on lymphocyte activation in vitro have been studied. Aspirin inhibits lymphocyte activation when measured by protein synthesis or by 3H-thymidine incorporation at therapeutic concentration. Dipyridamole also strongly inhibits 3H-thymidine incorporation, but is a less potent inhibitor of protein synthesis at therapeutic concentrations. Aspirin/dipyridamole combinations did not show synergism as inhibitors of lymphocyte activation. It is concluded that these drugs has dissimilar actions on the lymphocyte and that dipyridamole will not serve as an aspirin-sparing drug in anti-inflammatory therapy.
已经研究了阿司匹林和双嘧达莫在体外对淋巴细胞活化的作用。当通过蛋白质合成或在治疗浓度下通过3H-胸苷掺入来测量时，阿司匹林可抑制淋巴细胞活化。双嘧达莫也强烈抑制3H-胸苷掺入，但在治疗浓度下对蛋白质合成的抑制作用较弱。阿司匹林/双嘧达莫组合作为淋巴细胞活化抑制剂未显示出协同作用。得出的结论是，这些药物对淋巴细胞具有不同的作用，并且双嘧达莫在抗炎治疗中不能作为减少阿司匹林用量的药物。
