Stark M J, Campbell B K
Oregon Health Division, Portland 97232.
Am J Drug Alcohol Abuse. 1993;19(2):209-17. doi: 10.3109/00952999309002681.
Cigarette smoking has been shown to increase consequent to the acute administration of methadone. This suggests the possibility that differences in maintenance dose levels might be associated with differential smoking rates. It is of special concern that higher maintenance levels of methadone may lead to more cigarette smoking because of the putative beneficial effects of higher doses on illicit drug use, treatment retention, and the like. Two experiments were conducted to test the hypothesis that higher maintenance doses of methadone are related to more cigarette smoking. Smoking was measured by self-report and expired carbon monoxide, and the amounts were correlated with subjects' methadone dose levels. The results showed smoking rates of 85% and that self-reported smoking significantly correlated (r = -.52) with CO. Maintenance doses, however, were not correlated with smoking levels. This suggests that the acute effects of methadone on smoking are nullified as clients habituate to dose level, and that decisions regarding appropriate methadone dosage can be made on other grounds.
已表明，在急性给予美沙酮后吸烟会增加。这表明维持剂量水平的差异可能与不同的吸烟率相关。特别令人担忧的是，较高的美沙酮维持水平可能导致更多吸烟，因为较高剂量对非法药物使用、治疗留存率等可能有假定的有益影响。进行了两项实验来检验美沙酮较高维持剂量与更多吸烟有关这一假设。通过自我报告和呼出一氧化碳来测量吸烟情况，并将其数量与受试者的美沙酮剂量水平相关联。结果显示吸烟率为85%，且自我报告的吸烟情况与一氧化碳显著相关（r = -0.52）。然而，维持剂量与吸烟水平不相关。这表明随着患者对剂量水平产生耐受性，美沙酮对吸烟的急性影响会消失，并且可以基于其他理由做出关于适当美沙酮剂量的决定。
