Doménech J, Cuchí M A, Fusté J, Traserra Coderch J
Catedra de O.R.L., Facultad de Medicina (Hospital Clinic), Universidad de Barcelona.
An Otorrinolaringol Ibero Am. 1993;20(2):173-8.
Josamycin is an antibiotic macrolide similar to erythromycin, with some differences in its biologic behaviour. There have been no reports of ototoxic effects caused by this drug, but its similitudes with erythromycin have prompted us to undertake a study about its possible cochleo-toxicity. Most trials of this kind have been carried out using conventional audiometry (up to 8,000 Hz), thus not being able to detect threshold shifts above this frequency. Ototoxic lesions usually begin in the upper frequency limit. Twenty-eight patients without previous auditory impairment were studied with conventional (up to 8,000 Hz) and high-frequency audiometry (up to 20,000 Hz) before and after oral treatment with josamycin during eight days. No significant differences were found in auditory thresholds registered before and after treatment in any of the patients. These results suggest that josamycin is devoid of any cochleo-toxic effect in all the frequencies that a normal subject can hear.
交沙霉素是一种与红霉素类似的大环内酯类抗生素，其生物学行为存在一些差异。尚无关于该药物引起耳毒性作用的报道，但其与红霉素的相似性促使我们开展一项关于其可能的耳蜗毒性的研究。此类大多数试验是使用传统听力测定法（高达8000赫兹）进行的，因此无法检测高于该频率的阈值变化。耳毒性损害通常始于高频上限。对28例既往无听力损害的患者在口服交沙霉素治疗八天前后进行了传统（高达8000赫兹）和高频听力测定（高达20000赫兹）研究。在任何患者中，治疗前后记录的听觉阈值均未发现显著差异。这些结果表明，在正常受试者能够听到的所有频率中，交沙霉素没有任何耳蜗毒性作用。
