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Thioredoxin from activated macrophages as a trophic factor for central cholinergic neurons in vitro.

作者信息

Endoh M, Kunishita T, Tabira T

机构信息

Division of Demyelinating Disease and Aging, National Institute of Neuroscience, NCNP, Tokyo, Japan.

出版信息

Biochem Biophys Res Commun. 1993 Apr 30;192(2):760-5. doi: 10.1006/bbrc.1993.1479.

DOI:10.1006/bbrc.1993.1479
PMID:8484782
Abstract

The conditioned medium from gamma-interferon-stimulated macrophages elevated the choline acetyltransferase activity in mouse septal neurons as well as in cholinergic hybrid cell lines SN6.10.2.2 in vitro. After purification and sequencing, the active fraction was identical to thioredoxin (TRX), and the neurotrophic activity of recombinant TRX was confirmed.

摘要

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