使用典型相关分析对具有复合反应和复合剂量的多变量平行线生物测定进行分析。

Analysis of multivariate parallel-line bioassay with composite responses and composite doses, using canonical correlations.

作者信息

Yuan W, Kshirsagar A M

机构信息

Department of Biostatistics, University of Michigan, Ann Arbor.

出版信息

J Biopharm Stat. 1993 Mar;3(1):57-71. doi: 10.1080/10543409308835048.

DOI:10.1080/10543409308835048

PMID:8485536

Abstract

The use of a composite response to estimate the relative potency in a multivariate parallel-line bioassay is described by Finney. Occasionally a multivariate bioassay has multiple drugs also. Such a situation arises, for example, when a treatment contains several drugs. A procedure for combining multiple responses and combining multiple drugs is proposed in this paper, in order to obtain point and interval estimates of the relative potency. A composite response and a composite dose level for this purpose are obtained by using canonical analysis.

摘要

芬尼描述了在多变量平行线生物测定中使用复合反应来估计相对效价的方法。偶尔，多变量生物测定也会有多种药物。例如，当一种治疗包含几种药物时，就会出现这种情况。本文提出了一种将多个反应和多种药物相结合的方法，以获得相对效价的点估计和区间估计。为此，通过典型分析获得复合反应和复合剂量水平。