Widimský J, Horký K
III. interní klinika 1. LF UK, Praha.
Cas Lek Cesk. 1993 Apr 5;132(7):215-8.
Endothelin is a recently discovered peptide which is formed in the endothelial layer of the vascular wall and is released, following different stimuli, into the neighbouring smooth muscle layer of blood vessels and into the vascular lumen. By its effects on the regulation of the vascular tonus endothelin could play a part in regulating the function of various organ systems. The submitted paper gives a brief account on contemporary knowledge regarding the formation, elimination and biological effects of endothelin. The authors discuss also the potential physiological and pathophysiological role of this peptide.
内皮素是一种最近发现的肽，它在血管壁的内皮层形成，并在不同刺激下释放到邻近的血管平滑肌层和血管腔中。通过对血管张力调节的影响，内皮素可能在调节各种器官系统的功能中发挥作用。提交的论文简要介绍了关于内皮素的形成、消除和生物学效应的当代知识。作者还讨论了这种肽潜在的生理和病理生理作用。
