Resl M, Otcenásek M, Steiner I
Fingerlandův ústav patologie LF UK, Hradec Králové.
Cesk Patol. 1993 Feb;29(1):32-5.
There is an increasing frequency of heart mycoses. Authors identified 19 such cases between 1972 and 1991, 63% in the last 6 years (frequency was 0.1% in 17.661 autopsies of patients over 7 days of life). Males prevailed (17:2). Yeasts of genus Candida dominated, unusual etiology represented Candida parapsilosis, Torulopsis candida and Aspergillus restrictus. Sampling from vegetations or abscesses was a prerequisite for positive autoptic cultivation. Probable source of infection was found in 12 patients and 5 of them had an infected thrombosis of venous catheter. Mycosepsis comprised nearly equal number of endocarditides (mostly left sided) and myocarditides. Spread of endocardial infection into myocardium was rare, most myocarditides resulted from disseminated infection in immunocompromised patients. Endocarditides mainly complicated surgical interventions.
心脏霉菌感染的发生率呈上升趋势。作者在1972年至1991年间确认了19例此类病例,其中63%发生在过去6年(在17661例7天以上存活患者的尸检中发生率为0.1%)。男性居多(17例男性,2例女性)。念珠菌属酵母菌占主导,不常见的病原体包括近平滑念珠菌、假丝酵母样球拟酵母和局限曲霉。从赘生物或脓肿取样是尸检培养呈阳性的前提条件。在12例患者中发现了可能的感染源,其中5例有静脉导管感染性血栓形成。真菌败血症中的心内膜炎(大多为左侧)和心肌炎数量几乎相等。心内膜感染扩散至心肌的情况罕见,大多数心肌炎是免疫功能低下患者播散性感染所致。心内膜炎主要并发于外科手术。