d-α-生育酚抑制低密度脂蛋白诱导的血管平滑肌细胞增殖和蛋白激酶C活性。
d-alpha-Tocopherol inhibits low density lipoprotein induced proliferation and protein kinase C activity in vascular smooth muscle cells.
作者信息
Ozer N K, Palozza P, Boscoboinik D, Azzi A
机构信息
Institut für Biochemie und Molekularbiologie, Universität Bern, Switzerland.
出版信息
FEBS Lett. 1993 May 17;322(3):307-10. doi: 10.1016/0014-5793(93)81592-n.
PMID:8486164
Abstract
Native and malondialdehyde modified low density lipoproteins have been shown to stimulate smooth muscle cell proliferation (A7r5) in vitro. The stimulation is associated with an increase of protein kinase C activity. d-alpha-Tocopherol, at physiological concentrations, has been found to inhibit both protein kinase C activity and cell proliferation.
摘要
天然和丙二醛修饰的低密度脂蛋白已被证明在体外可刺激平滑肌细胞（A7r5）增殖。这种刺激与蛋白激酶C活性增加有关。已发现生理浓度的d-α-生育酚可抑制蛋白激酶C活性和细胞增殖。
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