Boscoboinik D, Szewczyk A, Azzi A
Institut für Biochemie und Molekularbiologie, Universität Bern, Switzerland.
Arch Biochem Biophys. 1991 Apr;286(1):264-9. doi: 10.1016/0003-9861(91)90039-l.
Alpha-Tocopherol (vitamin E) protects against free radical damage, which has been implicated in aging, cancer initiation, and atherosclerosis. We have found that physiological concentrations of alpha-tocopherol specifically inhibited aorta smooth muscle cell (VSMC, line A7r5) proliferation and protein kinase C (PKC) activity. Other water and lipid soluble antioxidants were inactive. alpha-Tocopherol inhibition of PKC and of VSMC proliferation may represent a physiological mechanism, relevant to the onset of diseased states such as atherosclerosis.
α-生育酚（维生素E）可防止自由基损伤，而自由基损伤与衰老、癌症发生及动脉粥样硬化有关。我们发现，生理浓度的α-生育酚能特异性抑制主动脉平滑肌细胞（VSMC，A7r5系）增殖及蛋白激酶C（PKC）活性。其他水溶性和脂溶性抗氧化剂则无此作用。α-生育酚对PKC及VSMC增殖的抑制作用可能代表一种与动脉粥样硬化等疾病状态发生相关的生理机制。
