Timomirova M M, Beliatskaia O Ia
Genetika. 1993 Mar;29(3):444-8.
It has been demonstrated that heat resistance (and radiosensitivity) of the germ cells at all stages of oogenesis in the females of heat resistant drosophila line (T) is being formed during ontogenesis and depends on the environmental temperature. These characteristics were retained at the stage of imago, even in the cases of temperature changes (from +32 to +25 degrees C, or from +25 to +32 degrees C). The intensity of induced mutagenesis (by X-rays and high temperature) which was evaluated for the frequency of dominant lethal mutations and X-chromosome loss depended on the temperature during development, but depends on no temperature at the time of treating imago with the mutagenic agents. It is suggested to be a result of the participation of heat shock proteins in repair of DNA damages.
已经证明，耐热果蝇品系（T）雌性个体在卵子发生各阶段生殖细胞的耐热性（和放射敏感性）是在个体发育过程中形成的，并取决于环境温度。即使在温度变化的情况下（从+32摄氏度到+25摄氏度，或从+25摄氏度到+32摄氏度），这些特征在成虫阶段也得以保留。通过显性致死突变频率和X染色体丢失频率评估的诱导诱变强度（通过X射线和高温）取决于发育期间的温度，但在用诱变剂处理成虫时不取决于温度。这被认为是热休克蛋白参与DNA损伤修复的结果。
