Roessner C A, Min C, Hardin S H, Harris-Haller L W, McCollum J C, Scott A I
Department of Chemistry, Texas A & M University, College Station 77843-3255.
Gene. 1993 May 15;127(1):149-50. doi: 10.1016/0378-1119(93)90631-c.
The nucleotide sequence of the Candida albicans erg7 gene, which complements erg7 mutants of Saccharomyces cerevisiae and restores oxidosqualene cyclase activity, was determined. The gene encodes a 728-aa protein that displays homology with squalene-hopene cyclase, providing further evidence that erg7 is the gene encoding 2,3-oxidosqualene cyclase.
已确定白色念珠菌erg7基因的核苷酸序列，该基因可互补酿酒酵母的erg7突变体并恢复氧化角鲨烯环化酶活性。该基因编码一种728个氨基酸的蛋白质，与角鲨烯-藿烯环化酶具有同源性，这进一步证明erg7是编码2,3-氧化角鲨烯环化酶的基因。
