Gordon C R, Kuritzky A, Doweck I, Spitzer O, Shupak A, Hering R
Motion Sickness and Human Performance Laboratory, Israeli Naval Hyperbaric Institute, Haifa.
Headache. 1993 Mar;33(3):129-32. doi: 10.1111/j.1526-4610.1993.hed3303129.x.
We studied vestibulo-ocular reflex measurements in a group of 12 patients suffering from migraine without aura and evaluated the effect of sodium valproate given as prophylactic migraine therapy. The study was randomized, double blind and placebo controlled, with a crossover design. The horizontal vestibulo-ocular reflex was evaluated by the Sinusoidal Harmonic Acceleration test at 0.01, 0.02, 0.04, 0.08 and 0.16 Hz using a computerized rotatory chair system. No abnormalities were found for the vestibulo-ocular reflex gain, phase and asymmetry at each of the frequencies examined during the placebo treatment. These normal vestibulo-ocular reflex measurements contrasted with the repeated complaints of dizziness, vertigo and unsteadiness reported by 7 patients (58%). Sodium valproate affected neither vestibulo-ocular responses nor vestibular complaints but was effective in reducing migraine attacks in 8 of the 12 patients. These results demonstrate that the low frequency vestibulo-ocular reflex measurements are normal in patients suffering from migraine without aura.
我们对一组12例无先兆偏头痛患者进行了前庭眼反射测量，并评估了丙戊酸钠作为偏头痛预防性治疗的效果。该研究采用随机、双盲、安慰剂对照的交叉设计。使用计算机化转椅系统，通过正弦谐波加速度测试在0.01、0.02、0.04、0.08和0.16Hz频率下评估水平前庭眼反射。在安慰剂治疗期间，在所检查的每个频率下，前庭眼反射增益、相位和不对称性均未发现异常。这些正常的前庭眼反射测量结果与7例患者（58%）反复出现的头晕、眩晕和不稳主诉形成对比。丙戊酸钠既不影响前庭眼反应，也不影响前庭主诉，但对12例患者中的8例有效减少偏头痛发作。这些结果表明，无先兆偏头痛患者的低频前庭眼反射测量结果正常。
