Kambe M, Morishita K, Tsubokura T, Tsuno K, Kimura T, Utsumi T, Kawamoto H, Yamakido M, Mittman C
Department of Clinical Pathology, Hiroshima University, School of Medicine, Hiroshima, Japan.
Hiroshima J Med Sci. 1993 Mar;42(1):41-5.
Laurel and Eriksson published the first report indicating that alpha 1-antitrypsin deficiency predisposed patients to the development of Chronic Obstructive Pulmonary Disease (COPD). For the purpose of early detection, disturbances of pulmonary function in alpha 1-antitrypsin mild deficiency cases (PiMZ) were compared with those of normal cases (PiMM) in caucasian Americans. The marked results are as follows. 1) Parameters of flow-volume curves were more disturbed in PiMZ cases than in PiMM cases. 2) Volumes of isoflow are specially different between PiMZ and PiMM cases. 3) Mechanical properties, like lung work of breathing, were larger in PiMZ cases than in PiMM cases.
劳雷尔和埃里克森发表了首份报告，指出α1抗胰蛋白酶缺乏症使患者易患慢性阻塞性肺疾病（COPD）。为了早期检测，在高加索裔美国人中，将轻度α1抗胰蛋白酶缺乏症病例（PiMZ）的肺功能障碍与正常病例（PiMM）进行了比较。显著结果如下：1）PiMZ病例的流量-容积曲线参数比PiMM病例受到的干扰更大。2）PiMZ和PiMM病例之间等流量容积存在特别差异。3）PiMZ病例的机械性能，如呼吸肺功，比PiMM病例更大。
