Husain K, Vijayaraghavan R, Pant S C, Raza S K, Pandey K S
Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior, India.
J Appl Toxicol. 1993 Mar-Apr;13(2):143-5. doi: 10.1002/jat.2550130212.
Delayed neurotoxicity of sarin in mice after repeated inhalation exposure has been studied. Female mice exposed to atmospheric sarin (5 mg m-3 for 20 min) daily for 10 days developed muscular weakness of the limbs and slight ataxia on the 14th day after the start of the exposure. These changes were accompanied by significant inhibition of neurotoxic esterase (NTE) activity in the brain, spinal cord and platelets. Histopathology of the spinal cord of exposed animals showed focal axonal degeneration. These changes were comparatively less than in animals treated with the neurotoxic organophosphate, mipafox. Results from this study indicate that sarin may induce delayed neurotoxic effects in mice following repeated inhalation exposure.
已对小鼠反复吸入暴露后沙林的迟发性神经毒性进行了研究。雌性小鼠每天暴露于大气中的沙林（5毫克/立方米，持续20分钟），持续10天，在暴露开始后的第14天出现四肢肌肉无力和轻微共济失调。这些变化伴随着大脑、脊髓和血小板中神经毒性酯酶（NTE）活性的显著抑制。暴露动物脊髓的组织病理学显示局灶性轴突变性。这些变化比用神经毒性有机磷酸酯米帕明治疗的动物要小。这项研究的结果表明，反复吸入暴露后，沙林可能会在小鼠中诱发迟发性神经毒性作用。
