Smulian A G, Sullivan D W, Linke M J, Halsey N A, Quinn T C, MacPhail A P, Hernandez-Avila M A, Hong S T, Walzer P D
VA Medical Center, Cincinnati, Ohio.
J Infect Dis. 1993 May;167(5):1243-7. doi: 10.1093/infdis/167.5.1243.
The reported incidence of Pneumocystis carinii pneumonia varies in different areas of the world, but little is known about geographic variation in the antibody response to specific antigens. The frequency of anti-P. carinii antibodies in the serum of normal and human immunodeficiency virus (HIV)-infected individuals from five different regions was compared. Serum specimens from 948 subjects were assayed for IgG antibodies to human-derived P. carinii by Western blot. The overall prevalence of anti-P. carinii antibodies was 72.9%. Among HIV-seronegative individuals, the rate of seropositivity was similar in all regions (70.5%-82.4%). Antibodies to the 30- to 40-kDa antigen were most commonly detected. The frequency of antibodies to high-molecular-mass antigens (95, 120, and > 120 kDa) demonstrated significant geographic variation. This study demonstrates that antibody responses to P. carinii are common in all areas studied but vary in frequency and pattern.
卡氏肺孢子虫肺炎的报告发病率在世界不同地区有所不同，但对于针对特定抗原的抗体反应的地理差异知之甚少。比较了来自五个不同地区的正常人和感染人类免疫缺陷病毒（HIV）个体血清中抗卡氏肺孢子虫抗体的频率。通过蛋白质印迹法检测了948名受试者血清标本中针对人源卡氏肺孢子虫的IgG抗体。抗卡氏肺孢子虫抗体的总体患病率为72.9%。在HIV血清阴性个体中，所有地区的血清阳性率相似（70.5%-82.4%）。最常检测到针对30至40 kDa抗原的抗体。针对高分子量抗原（95、120和>120 kDa）的抗体频率显示出显著的地理差异。这项研究表明，在所有研究地区，针对卡氏肺孢子虫的抗体反应都很常见，但频率和模式有所不同。
