Hill S Y, Steinhauer S R
Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213.
J Stud Alcohol. 1993 May;54(3):350-8. doi: 10.15288/jsa.1993.54.350.
A total of 86 children (45 male) between the ages of 8-18 who were from families that were either at high- or low-risk for developing alcoholism were evaluated in a visual event-related potential paradigm. The children responded to two target conditions (hard and easy) and a blank condition by pressing an appropriate button. P300 amplitude was reduced in prepubescent boys who were at high-risk for developing alcoholism. Reaction time data for type of target indicated that, while latency was longer for the hard condition compared to the easy one, no significant differences by risk status were found. Performance accuracy did not differ by group status. These behavioral findings suggest that P300 amplitude is an electrophysiological marker of alcoholism risk in young boys.
共有86名8至18岁的儿童（45名男性）参与了一项视觉事件相关电位范式评估，这些儿童来自酗酒风险高或低的家庭。儿童通过按下相应按钮对两种目标条件（难和易）及空白条件做出反应。处于酗酒高风险的青春期前男孩的P300波幅降低。目标类型的反应时间数据表明，虽然难条件下的潜伏期比易条件下更长，但未发现风险状态存在显著差异。不同组别的表现准确性没有差异。这些行为学研究结果表明，P300波幅是年轻男孩酗酒风险的一种电生理标志物。
