Ramsey S E, Finn P R
Department of Psychology, Indiana University, Bloomington 47405, USA.
J Stud Alcohol. 1997 Nov;58(6):606-16. doi: 10.15288/jsa.1997.58.606.
Males with a family history of alcoholism (Family History Positive [FHP]) have frequently been reported to show an attenuated amplitude of the P300 component of the EEG event-related potential (ERP). The purpose of the present study was to explore the influence of incentives on the amplitude of the P300 to Target stimuli in FHP and FHN (Family History Negative) men.
The ERPs of 20 FHP and 20 FHN men were recorded in a visual discrimination task under two conditions: a no incentive (Neutral) and a reward/loss of reward (Incentive) conditions. ERPs following Target, Non-Target and Novel stimuli were examined.
The FHP subjects displayed the expected attenuation of P300 amplitude, regardless of the stimulus type (Target, Non-Target or Novel), compared to the FHN subjects. The FHN subjects showed the predicted effect of a significantly increased P300 amplitude following Target stimuli in the Incentive condition whereas the FHP subjects did not display significantly greater P300 amplitudes in response to the incentive.
These results may reflect a deficit in the motivational-cognitive system of FHP subjects. Analyses suggest that changes in P300 amplitude in response to the incentive can be predicted by subjects' scores on self-report measures of sensation seeking and behavioral undercontrol. However, such measures could not explain subjects' absolute P300 amplitude to Target stimuli.
有酗酒家族史的男性（家族史阳性[FHP]）经常被报道脑电图事件相关电位（ERP）的P300成分波幅减弱。本研究的目的是探讨奖励对FHP和FHN（家族史阴性）男性对目标刺激的P300波幅的影响。
20名FHP男性和20名FHN男性的ERP在视觉辨别任务中的两种条件下被记录：无奖励（中性）和奖励/无奖励（奖励）条件。对目标、非目标和新刺激后的ERP进行检查。
与FHN受试者相比，FHP受试者无论刺激类型（目标、非目标或新刺激）如何，均表现出预期的P300波幅减弱。FHN受试者在奖励条件下对目标刺激后P300波幅显著增加，而FHP受试者对奖励没有表现出显著更大的P300波幅。
这些结果可能反映了FHP受试者动机-认知系统的缺陷。分析表明，受试者在感觉寻求和行为控制不足的自我报告测量中的得分可以预测对奖励的P300波幅变化。然而，这些测量无法解释受试者对目标刺激的绝对P300波幅。
