Petit D, Lorrain D, Gauthier S, Montplaisir J
Centre d'Etude du Sommeil, Hôpital du Sacré-Coeur, Gouin Ouest, Montréal (Québec), Canada.
Neurobiol Aging. 1993 Mar-Apr;14(2):141-5. doi: 10.1016/0197-4580(93)90089-t.
Regional spectral analyses of the EEG during wakefulness and REM sleep was performed in eight patients with mild to moderate Alzheimer's disease and compared to that of healthy age-matched controls. Alzheimer patients presented some EEG slowing in frontal, parieto-occipital and temporal regions in the waking state. However, this EEG slowing was much better revealed in REM sleep, whether expressed by the ratio of slow to fast frequencies or by changes in each of the frequency bands. Moreover, regional differences in EEG slowing, relatively nonexistent in the awake EEG, were a prominent feature of the REM sleep EEG. Importance of cholinergic basal forebrain in the desynchronization of the REM sleep EEG might explain these results because this structure is affected in early Alzheimer's disease.
对8例轻度至中度阿尔茨海默病患者在清醒和快速眼动睡眠期间进行脑电图区域频谱分析，并与年龄匹配的健康对照者进行比较。阿尔茨海默病患者在清醒状态下额叶、顶枕叶和颞叶区域出现一些脑电图减慢。然而，无论是以慢频率与快频率的比率还是以每个频段的变化来表示，这种脑电图减慢在快速眼动睡眠中表现得更为明显。此外，脑电图减慢的区域差异在清醒脑电图中相对不存在，是快速眼动睡眠脑电图的一个突出特征。胆碱能基底前脑在快速眼动睡眠脑电图去同步化中的重要性可能解释了这些结果，因为该结构在早期阿尔茨海默病中受到影响。
