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一种中药十全大补汤单独或与5-氟尿嘧啶衍生物联合应用对1,2-二甲基肼诱导的大鼠结肠癌DNA合成酶的抗癌作用。

Anticancer effects of a Chinese herbal medicine, juzen-taiho-to, in combination with or without 5-fluorouracil derivative on DNA-synthesizing enzymes in 1,2-dimethylhydrazine induced colonic cancer in rats.

作者信息

Sakamoto S, Kudo H, Kuwa K, Suzuki S, Kato T, Kawasaki T, Nakayama T, Kasahara N, Okamoto R

机构信息

Medical Research Institute, Tokyo Medical and Dental University, Japan.

出版信息

Am J Chin Med. 1991;19(3-4):233-41. doi: 10.1142/S0192415X91000314.

DOI:10.1142/S0192415X91000314
PMID:1767795
Abstract

Juzen-taiho-to (JTT; [Shi-quan-da-bu-tang], a Japanese modified Chinese herbal prescription) in combination with an anticancer drug UFT (5-fluorouracil derivative) prevented the body weight loss and the induction of the colonic cancer in rats treated with a chemical carcinogen 1,2-dimethylhydrazine (DMH), and suppressed markedly the activity of thymidylate synthetase (TS) involved in the de novo pathway of pyrimidine synthesis in colonic cancer induced by DMH.

摘要

十全大补汤（JTT；[十全大补汤]，一种日本改良的中药方剂）与抗癌药物优福定（5-氟尿嘧啶衍生物）联合使用，可防止用化学致癌物1,2-二甲基肼（DMH）处理的大鼠体重减轻和结肠癌的诱发，并显著抑制DMH诱导的结肠癌中参与嘧啶合成从头途径的胸苷酸合成酶（TS）的活性。

相似文献

1
Anticancer effects of a Chinese herbal medicine, juzen-taiho-to, in combination with or without 5-fluorouracil derivative on DNA-synthesizing enzymes in 1,2-dimethylhydrazine induced colonic cancer in rats.一种中药十全大补汤单独或与5-氟尿嘧啶衍生物联合应用对1,2-二甲基肼诱导的大鼠结肠癌DNA合成酶的抗癌作用。
Am J Chin Med. 1991;19(3-4):233-41. doi: 10.1142/S0192415X91000314.
2
Effects of kampo (Japanese herbal) medicine "sho-saiko-to" on DNA-synthesizing enzyme activity in 1,2-dimethylhydrazine-induced colonic carcinomas in rats.汉方（日本草药） medicine “小柴胡汤” 对1,2 - 二甲基肼诱导的大鼠结肠癌中DNA合成酶活性的影响。
Planta Med. 1993 Apr;59(2):152-4. doi: 10.1055/s-2006-959632.
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Thymidylate synthetase and thymidine kinase activities in DMH-induced colon carcinomas in rats and effects of UFT.二甲基肼诱导的大鼠结肠癌中胸苷酸合成酶和胸苷激酶活性及优福定的作用
Bull Tokyo Med Dent Univ. 1986 Dec;33(4):137-44.
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[Effects of hyperthermochemotherapy on activities of DNA-synthesizing enzymes in 1, 2-dimethylhydrazine (DMH)-induced colon carcinomas in rats].[高温化疗对1,2-二甲基肼（DMH）诱导的大鼠结肠癌中DNA合成酶活性的影响]
Nihon Gan Chiryo Gakkai Shi. 1990 Jun 20;25(6):1190-6.
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Preventive effect of 1-(2-tetrahydrofuryl)-5-fluorouracil in combination with uracil on colonic carcinogenesis induced by 1,2-dimethylhydrazine in rats.1-(2-四氢呋喃基)-5-氟尿嘧啶联合尿嘧啶对大鼠1,2-二甲基肼诱导的结肠癌发生的预防作用
Cancer Detect Prev. 1997;21(4):340-5.
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[The effect of UFT on thymidine kinase and thymidylate synthetase activities and autoradiograph in DMH-induced colon cancer in rat].[优福定对二甲基肼诱导的大鼠结肠癌中胸苷激酶、胸苷酸合成酶活性及放射自显影的影响]
Nihon Gan Chiryo Gakkai Shi. 1987 Jul 20;22(6):1169-75.
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Effects of Chinese herbal medicines on DNA-synthesizing enzyme activities in mammary tumors of mice.中药对小鼠乳腺肿瘤中DNA合成酶活性的影响。
Am J Chin Med. 1994;22(1):43-50. doi: 10.1142/S0192415X94000061.
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Activities of thymidylate synthetase and thymidine kinase in gastric cancer.胃癌中胸苷酸合成酶和胸苷激酶的活性
Surg Oncol. 1992 Jun;1(3):215-21. doi: 10.1016/0960-7404(92)90067-u.
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[Effects of SSM (purified polysaccharides from human tubercle bacillus, maruyama vaccine) and UFT (a combination of tegafur and uracil) on DNA-synthesizing enzyme activities in 1,2-dimethylhydrazine (DMH)-induced rat colon carcinomas].[人结核杆菌纯化多糖SSM（丸山疫苗）和替加氟尿嘧啶（替加氟与尿嘧啶的组合）对1,2 - 二甲基肼（DMH）诱导的大鼠结肠癌中DNA合成酶活性的影响]
Nihon Gan Chiryo Gakkai Shi. 1987 Oct 20;22(9):2239-45.
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Effect of interferon-alpha A/D in combination with the Japanese and Chinese traditional herbal medicine juzen-taiho-to on lung metastasis of murine renal cell carcinoma.α干扰素A/D联合日本和中国传统草药十全大补汤对小鼠肾细胞癌肺转移的影响。
Anticancer Res. 2000 Sep-Oct;20(5A):2931-7.

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