一种中药十全大补汤单独或与5-氟尿嘧啶衍生物联合应用对1,2-二甲基肼诱导的大鼠结肠癌DNA合成酶的抗癌作用。
Anticancer effects of a Chinese herbal medicine, juzen-taiho-to, in combination with or without 5-fluorouracil derivative on DNA-synthesizing enzymes in 1,2-dimethylhydrazine induced colonic cancer in rats.
作者信息
Sakamoto S, Kudo H, Kuwa K, Suzuki S, Kato T, Kawasaki T, Nakayama T, Kasahara N, Okamoto R
机构信息
Medical Research Institute, Tokyo Medical and Dental University, Japan.
出版信息
Am J Chin Med. 1991;19(3-4):233-41. doi: 10.1142/S0192415X91000314.
Juzen-taiho-to (JTT; [Shi-quan-da-bu-tang], a Japanese modified Chinese herbal prescription) in combination with an anticancer drug UFT (5-fluorouracil derivative) prevented the body weight loss and the induction of the colonic cancer in rats treated with a chemical carcinogen 1,2-dimethylhydrazine (DMH), and suppressed markedly the activity of thymidylate synthetase (TS) involved in the de novo pathway of pyrimidine synthesis in colonic cancer induced by DMH.
十全大补汤（JTT；[十全大补汤]，一种日本改良的中药方剂）与抗癌药物优福定（5-氟尿嘧啶衍生物）联合使用，可防止用化学致癌物1,2-二甲基肼（DMH）处理的大鼠体重减轻和结肠癌的诱发，并显著抑制DMH诱导的结肠癌中参与嘧啶合成从头途径的胸苷酸合成酶（TS）的活性。
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