Otsuka M, Meistrich M L
Department of Experimental Radiotherapy, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Radiat Res. 1993 May;134(2):247-50.
Following irradiation of a single kidney in mice, the weights and labeling indices in the irradiated and contralateral unirradiated kidneys were measured. Three to 12 months after irradiation we found that the proliferation of proximal tubule cells was increased not only in the irradiated kidney but also in the contralateral unirradiated kidney. The labeling index in the contralateral unirradiated kidney did not increase in the first month after irradiation but it did in the irradiated kidney. Contralateral kidney weight increased as the weight of the irradiated kidney decreased. We suggest that cell proliferation in the contralateral kidney was probably induced through a humoral growth factor beginning 3 months after irradiation. We postulate that induced cell proliferation in the irradiated kidney is a result of a local factor at 1 month and of local and humoral factors at later times.
对小鼠的一个肾脏进行照射后，测量了照射侧肾脏和对侧未照射肾脏的重量及标记指数。照射后3至12个月，我们发现不仅照射侧肾脏近端小管细胞的增殖增加，对侧未照射肾脏的近端小管细胞增殖也增加。对侧未照射肾脏的标记指数在照射后第一个月没有增加，但照射侧肾脏的标记指数增加了。随着照射侧肾脏重量的减少，对侧肾脏重量增加。我们认为，对侧肾脏中的细胞增殖可能是在照射后3个月开始通过一种体液生长因子诱导的。我们推测，照射侧肾脏中诱导的细胞增殖在1个月时是局部因素的结果，而在后期是局部和体液因素共同作用的结果。
