Burgstaler E A, Pineda A A, Brecher M A
Section of Transfusion Medicine, Mayo Clinic, Rochester, Minnesota.
Transfusion. 1993 May;33(5):393-8. doi: 10.1046/j.1537-2995.1993.33593255599.x.
Two apheresis systems (COBE Spectra and Fenwal CS-3000 Plus with TNX-6 chamber [CS-3000 Plus]) were compared by using their yield predictors and maximum processing times in regard to platelet yields and processing times (n = 200 each). Platelet yields (n = 50 each) and white cell (WBC) content (n = 20 each) from procedures using the current software revision (3.6) on the Spectra and various interface offset (IO) settings on the CS-3000 Plus were also compared. Significantly higher median platelet yields (4.88 [range, 1.84-9.97] vs. 4.57 [range, 2.82-9.20] x 10(11) platelets) and frequency of components with > or = 6.0 x 10(11) platelets (31.5 vs. 21.5%) were found with the Spectra. In the study with Spectra and the CS-3000 Plus IO settings, IO-10 and IO-13, overall, produced the most platelets, although the differences were not significant. All Spectra collections tested had < 5 x 10(8) WBCs, and, depending on the software revision, had either 85 percent (revision 3.6) or 100 percent (revision 2.5) of components with < 5 x 10(6) WBCs. To ensure that 100 percent of components contained < 5 x 10(8) WBCs when the CS-3000 Plus was used, IO settings of 10 or less were required, and to ensure components with < 5 x 10(6) WBCs, only IO-6 could be used. Spectra and CS-3000 Plus were capable of collecting large doses of platelets (up to the equivalent of 18 units) in processing times of 67 to 100 minutes with < 5 x 10(6) WBCs.
通过使用血小板产量预测器和最大处理时间，对两种单采系统（COBE Spectra和配备TNX - 6腔室的Fenwal CS - 3000 Plus [CS - 3000 Plus]）在血小板产量和处理时间方面进行了比较（每种系统n = 200）。还比较了使用Spectra当前软件版本（3.6）的程序以及CS - 3000 Plus上各种接口偏移（IO）设置下的血小板产量（每种n = 50）和白细胞（WBC）含量（每种n = 20）。发现Spectra的中位数血小板产量显著更高（4.88 [范围，1.84 - 9.97] 对 4.57 [范围，2.82 - 9.20]×10¹¹个血小板），且血小板数≥6.0×10¹¹个的成分频率更高（31.5% 对 21.5%）。在Spectra和CS - 3000 Plus的IO设置（IO - 10和IO - 13）的研究中，总体上产生的血小板最多，尽管差异不显著。所有测试的Spectra采集物的白细胞数均<5×10⁸，并且根据软件版本，白细胞数<5×10⁶的成分占85%（版本3.6）或100%（版本2.5）。当使用CS - 3000 Plus时，为确保100%的成分白细胞数<5×10⁸，需要IO设置为10或更低，而要确保白细胞数<5×10⁶的成分，只能使用IO - 6。Spectra和CS - 3000 Plus能够在67至100分钟的处理时间内采集大量血小板（相当于18个单位），且白细胞数<5×10⁶。
