Segal A W, Abo A
Department of Medicine, University College London, Rayne Institute, UK.
Trends Biochem Sci. 1993 Feb;18(2):43-7. doi: 10.1016/0968-0004(93)90051-n.
The NADPH oxidase is an electron transport chain found in lymphocytes and in the wall of the endocytic vacuole of 'professional' phagocytic cells. It is so called because NADPH is used as an electron donor to reduce oxygen to superoxide and hydrogen peroxide. The redox components are provided by a very unusual flavocytochrome b from the membrane, which is dependent upon cytosolic factors (including two specialized proteins, p47phox and p67phox) for activation. The small GTP-binding protein, p21rac, is also implicated in this system, possibly as the switch that triggers electron transport. This system provides a key to our understanding of the way in which these GTP-binding proteins function.
NADPH氧化酶是一种存在于淋巴细胞和“专职”吞噬细胞内吞泡壁中的电子传递链。之所以这样命名，是因为NADPH被用作电子供体，将氧气还原为超氧化物和过氧化氢。氧化还原成分由一种非常特殊的来自膜的黄素细胞色素b提供，它依赖于胞质因子（包括两种特殊蛋白质，p47phox和p67phox）来激活。小GTP结合蛋白p21rac也参与这个系统，可能作为触发电子传递的开关。这个系统为我们理解这些GTP结合蛋白的功能方式提供了关键。
