Daveau M, Pavie-Fischer J, Rivat L, Rivat C, Ropartz C, Peter H H, Cesarini J P, Kourilsky F M
Ann Immunol (Paris). 1977 Jan-Mar;128(1-2):113-6.
The 397 sera from 185 melanoma patients have been studied and classified in three groups according to the stage of disease. Our findings revealed an alteration of the level of IgG4 subclass which is related to the dissemination of disease. The percentage of abnormalities (either increased or decreased levels of IgG4) was more frequent in stage II and III (55% and 53% respectively) than in stage I (19%), The higher frequencies of high titers of IgG4 were essentially detected in advanced disease. The biological significance of the increase of IgG4 in melanoma remains obscure. It may be related to the development of facilitating antibodies of IgG4 subclass.
对185名黑色素瘤患者的397份血清进行了研究，并根据疾病分期分为三组。我们的研究结果显示，IgG4亚类水平的改变与疾病的扩散有关。异常百分比（IgG4水平升高或降低）在II期和III期（分别为55%和53%）比在I期（19%）更常见。高滴度IgG4的较高频率主要在晚期疾病中检测到。黑色素瘤中IgG4增加的生物学意义仍不清楚。它可能与IgG4亚类促进性抗体的产生有关。
