Daveau M, Pavie-Fischer J, Rivat L, Rivat C, Ropartz C, Peter H H, Cesarini J P, Kourilsky F M
J Natl Cancer Inst. 1977 Feb;58(2):189-92. doi: 10.1093/jnci/58.2.189.
Three hundred and ninety-seven sera from 185 melanoma patients were studied. These sera were classified into three groups according to stage of disease. An alteration in the level of the IgG4 subclass was found. It was related to the dissemination of disease. The percentage of abnormalities (either increased or decreased levels of IgG4) was more frequent in patients with stage II and III diseases (55 and 53%, respectively) than in patients with stage I(19%). The higher frequencies of high titers of IgG4 were essentially detected in advanced disease. The biologic significance of the increase of IgG4 in melanoma remains obscure. The increase may be related to the development of facilitating antibodies of the IgG4 subclass.
对185名黑色素瘤患者的397份血清进行了研究。这些血清根据疾病阶段分为三组。发现IgG4亚类水平发生了改变。这与疾病的扩散有关。II期和III期疾病患者中异常（IgG4水平升高或降低）的百分比（分别为55%和53%）比I期患者（19%）更常见。高滴度IgG4的较高频率主要在晚期疾病中检测到。黑色素瘤中IgG4增加的生物学意义仍不清楚。这种增加可能与IgG4亚类促进抗体的产生有关。
