Olson K N, Klein L V, Nann L E, Soma L R
Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square 19348.
Vet Surg. 1993 Jan-Feb;22(1):73-8. doi: 10.1111/j.1532-950x.1993.tb00374.x.
Six horses were administered isoflurane anesthesia by liquid injection into a closed breathing circuit according to the square root of time model. The unit dose (UD) was calculated using Lowe's formula to provide an end-tidal concentration of 1.3%, or the minimum alveolar concentration of isoflurane. The mean UD was 4.2 +/- 0.2 mL. The mean end-tidal isoflurane concentration (ETiso) for each interval after injection, and the peak and minimum concentrations for each injection interval, did not change beginning with the second injection, indicating that the square root of time model accurately predicted isoflurane uptake in the horse. Mean ETiso measured for the interval after the first injection was 0.68 +/- 0.06%, which was significantly (p < .05) lower than the mean concentration after all subsequent injections (1.1 +/- 0.1%). Mean peak end-tidal concentration was 1.1 +/- 0.25% after the first injection and 1.7 +/- 0.26% for all other injections. Mean minimum end-tidal concentration was 0.77 +/- 0.13% for all injection periods. This model proved to be an acceptable technique for administration of isoflurane anesthesia to horses.
根据时间平方根模型，通过液体注射将异氟烷麻醉剂注入封闭呼吸回路，对六匹马进行麻醉。使用洛氏公式计算单位剂量（UD），以提供1.3%的呼气末浓度，即异氟烷的最低肺泡浓度。平均UD为4.2 +/- 0.2 mL。注射后每个间隔的平均呼气末异氟烷浓度（ETiso），以及每个注射间隔的峰值和最低浓度，从第二次注射开始没有变化，这表明时间平方根模型准确预测了马体内异氟烷的摄取量。第一次注射后间隔测量的平均ETiso为0.68 +/- 0.06%，显著低于所有后续注射后的平均浓度（1.1 +/- 0.1%）（p < 0.05）。第一次注射后的平均呼气末峰值浓度为1.1 +/- 0.25%，其他所有注射的平均呼气末峰值浓度为1.7 +/- 0.26%。所有注射期间的平均呼气末最低浓度为0.77 +/- 0.13%。该模型被证明是一种给马施用异氟烷麻醉的可接受技术。
